To get to the Vatican Museums from Termini, you can take the Metro Line A towards Battistini and get off at Ottaviano. From there, the Vatican Museums are just a few minutes' walk away.
If you want more detail, travelling by metro is one of the quickest and most convenient ways to reach the Vatican Museums. Termini station is well connected and Line A of the metro will take you directly to the Vatican. Once you get off at the Ottaviano stop, follow the signs to the Vatican Museums, which are within easy walking distance. The route is well signposted and there are also many tourist signs along the way.
Alternatively, you can opt for a bus, but the journey may take longer due to traffic. Several bus lines connect Termini with the Vatican, but the metro is generally faster. If you prefer walking, the journey is about 2 kilometres and will allow you to enjoy the views of Rome along the way. Remember to check the opening hours of the Vatican Museums and, if possible, book tickets in advance to avoid long queues. This way, you can make the most of your visit and immerse yourself in the extraordinary art and history that the Vatican Museums have to offer.